Andrographis for Ulcerative Colitis

A 2013 study found that 1800mg daily of andrographis paniculata significantly improved symptoms of ulcerative colitis (60% vs 40%) compared to placebo over 8 weeks. Another study found similar clinical remission and response after 8 weeks with 1200mg daily of andrographis paniculata compared to 4500mg daily of mesalamine. Andrographis paniculata is thought to have anti-inflammatory effects. Andrographis paniculata may cause digestive or other side effects.

Tang T, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment Pharmacol Ther. 2011 Jan;33(2):194-202. doi: 10.1111/j.1365-2036.2010.04515.x. Epub 2010 Nov 30. PMID: 21114791.

Sandborn WJ, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013 Jan;108(1):90-8. doi: 10.1038/ajg.2012.340. Epub 2012 Oct 9. PMID: 23044768; PMCID: PMC3538174.