Perilla for Memory

A 2026 study found that a 500mg extract of perilla leaves daily significantly improved memory compared to placebo over 12 weeks. Another study in 2023 showed perilla seed oil may inhibit bone resorption and improve bone density. In high doses, perilla may cause nausea, headaches or other side effects.

Baek HI, Joo JC, Kim SK, Park MH, Cho GH, Shen L, Park SJ. Efficacy and Safety of Standardized Ethanol Extract of Purple Perilla (Perilla frutescens Britton var. acuta Kudo) Leaves in Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2026 Mar 18;18(6):960. doi: 10.3390/nu18060960. PMID: 41901135.

Matsuzaki K, Hossain S, Wakatsuki H, Tanabe Y, Ohno M, Kato S, Shido O, Hashimoto M. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial. Phytother Res. 2023 Jun;37(6):2230-2241. doi: 10.1002/ptr.7728. Epub 2023 Jan 13. PMID: 36637040.