Cannabidiol for Seizures

A 2017 study found that cannabidiol (CBD) at 20mg/kg per day in children was significantly more effective than placebo at reducing seizures over 14 weeks in children with a drug-resistant seizure disorder. Convulsive seizures decreased from a median of 12.4 to 5.9 per month in the CBD group vs 14.9 to 14.1 per month in the placebo group. There was no significant reduction in non-convulsive seizures. CBD may cause digestive or other side effects.

Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S; Cannabidiol in Dravet Syndrome Study Group. Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017 May 25;376(21):2011-2020. doi: 10.1056/NEJMoa1611618. PMID: 28538134.