American Skullcap for Insomnia

A 2025 study found that 400mg of American skullcap daily significantly improved sleep compared to placebo over 56 days in people with primary insomnia. Flavonoids in skullcap such as baicalein have been shown to bind to GABA receptors in the brain. American skullcap may cause dizziness or other side effects.

Di Minno A, Morone MV, Buccato DG, De Lellis LF, Ullah H, Piccinocchi R, Cordara M, Larsen DS, Di Guglielmo A, Baldi A, Piccinocchi G, Xiao X, Sacchi R, Daglia M. Efficacy and Tolerability of a Chemically Characterized Scutellaria lateriflora L. Extract-Based Food Supplement for Sleep Management: A Single-Center, Controlled, Randomized, Crossover, Double-Blind Clinical Trial. Nutrients. 2025 Apr 28;17(9):1491. doi: 10.3390/nu17091491. PMID: 40362800; PMCID: PMC12073644.