Silicone for Scars

Studies have shown that topical silicone can improve scar appearance. A 2019 study found that a new cream of highly selective growth factors in a silicone matrix leads to significantly better improvement in postsurgical scar appearance vs silicone alone over 12 weeks. A 2020 study also found that a similar cream containing growth factors and vitamins can significantly improve hyperpigmentation vs standard therapy. Topical silicone may cause irritation among other side effects.

Christopher I Zoumalan, Shiva C Tadayon, Jason Roostaeian, Anthony M Rossi, Allen Gabriel, Safety and Efficacy of a Scar Cream Consisting of Highly Selective Growth Factors Within a Silicone Cream Matrix: A Double-Blinded, Randomized, Multicenter Study, Aesthetic Surgery Journal, Volume 39, Issue 3, March 2019, Pages 319–330, https://doi.org/10.1093/asj/sjy185

Kalasho BD, Minokadeh A, Zhang-Nunes S, Zoumalan RA, Shemirani NL, Waldman AR, Pletzer V, Zoumalan CI. Evaluating the safety and efficacy of a new topical formulation for hyperpigmentation consisting of highly selective growth factors, tranexamic acid, and other ingredients to hydroquinone 4%: a prospective, randomized, controlled split face study. J Cosmet Sci. 2020 Sep/Oct;71(5):263-290.