Feverfew for Migraines

A 2005 study found that an extract of feverfew 6.25mg taken three times per day was significantly more effective than placebo at reducing the number of migraines per month over a period of 4 months. Feverfew may be less effective than typical medications used for migraine prevention, but side effects in trials have been fewer and less severe. Feverfew can cause gastrointestinal issues among other side effects. Feverfew is not safe to take during pregnancy.

Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia. 2005 Nov;25(11):1031-41. doi: 10.1111/j.1468-2982.2005.00950.x. PMID: 16232154.

NCCIH. “Feverfew.” NCCIH, Dec. 2020, www.nccih.nih.gov/health/feverfew.