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Boca Direct MD

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Cytisine for Smoking Cessation

Mar 9

Written By Graig Alpert

Cytisine may help people quit smoking — A 2025 study found that 3mg cytisnicline (cytisine) three times daily significantly improved smoking abstinence compared to placebo during the 12 week intervention. Cytisine is a natural plant alkaloid that binds selectively to α4β2 neuronal nicotinic acetylcholine receptors. Smoking abstinence was maintained for 20.5% of participants in the cytisine group vs 4.2% in the placebo group for up to 24 weeks (12 weeks after the cytisine was stopped). Cytisine may cause insomnia, nausea, headache or other side effects.

Rigotti NA, Benowitz NL, Prochaska JJ, Rubinstein M, Clarke A, Blumenstein B, Cain DF, Jacobs C. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. doi: 10.1001/jamainternmed.2025.0628. PMID: 40257755; PMCID: PMC12012700.

Graig Alpert

Chrysanthemum for Rosacea

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Disclaimer: The opinions expressed are meant for education only. They should not be used to diagnose or treat any medical condition nor should they be used as a substitute for medical advice from a qualified, board-certified physician. This content does not create a patient doctor relationship.